Is it December Already?


Can you believe it’s almost the end of 2016 and we’re only days away from starting a brand new year? I certainly can’t! There’s a laundry list of things that start over on January 1st, but the one we are concerned about is your insurance deductible which you worked so hard to meet in 2016. Luckily, December is the perfect time to get one last spinal tune up before the stress of the holidays sets in or to finally order that you’ve been putting off.

And since we’re on the subject of renewal, I’m proud to announce that I am expanding my nutritional consultation offerings and have added four new services to fit every budget and individual need.

Improving Your Diet – 45 minutes, $80

This 45 minute individualized session will include a review of your present diet with suggestions for making it more nutrient-dense, less inflammatory and more delicious.  Simple recipes included.

Food Sensitivities  – 1 hour, $120

During this session, we’ll dive-in together to figure out which foods may be causing your symptoms, from headaches to skin flare-ups to bloating and more.

Digestive Ailments /Digestive Wellness – 1 hour, $120

We’ll devote a whole hour to your unique digestive history including symptoms, cravings, medications, etc. and I’ll help you find digestive bliss.

Genetic variant testing – 45 minutes, $80 + testing fees ($250)

Thanks to new advances in technology and the mapping of the human genome, a simple saliva test today can measure 602,000 pieces of your DNA! This is an important development because everyone has some level of genetic variation in their DNA; and that can impact our ability to make and use critical enzymes, neurotransmitters and anti-oxidants. By identifying your variants or SNPs, we can specifically support the weak links nutritionally to improve a vast variety of minor and major diseases, sometimes with dramatic results.

Of course, I’m still offering my comprehensive 90 minute – 2 hour nutritional consultation for $275.  This option is strongly suggested for those with chronic and complex health issues such as auto-immune diseases.

Mention this newsletter and receive $20 off your next 2016 chiropractic adjustment or nutritional consult.

Hurry, offer expires December 31, 2016.


1/3 cup dried cranberries
1 bunch dinosaur kale (lacinato kale), ribs removed and leaves coarsely chopped
4 ounces baby spinach, chopped
1 ripe Asian pear, cored, halved and chopped
1 1/2 cups Overcooked Wild Rice (recipe follows) or Quinoa
1/2 cup toasted walnuts, coarsely chopped

Overcooked Wild Rice
1 1/2 cups wild rice
Kosher salt
Pomegranate Molasses Dressing
1/4 cup white wine vinegar
2 tablespoons pomegranate molasses
1 tablespoon clover honey
2 teaspoons Dijon mustard
Kosher salt and freshly ground black pepper
1/4 cup olive oil

Heartland Chopped Salad Directions

Bring 1 cup of water to a boil in a small saucepan, add the dried cranberries and let sit for 15 minutes. Drain off excess water.

Combine the kale, spinach, pear, Overcooked Wild Rice, walnuts and rehydrated cranberries in large bowl. Drizzle 1/4 cup of the Pomegranate Molasses Dressing over and gently toss until evenly coated. Transfer to a serving bowl and drizzle with more dressing when ready to serve.

Overcooked Wild Rice Directions

Combine the rice, 6 cups water and 1 tablespoon salt in a large saucepan, bring to a boil over high heat and cook until the grains open all the way, 1 hour 15 minutes to 1 hour 30 minutes. The rice should be very cooked (not even the slightest chewy). Drain well, spread on a baking sheet in an even layer and set aside. Allow to cool to room temperature. Yield: 3 cups

Pomegranate Molasses Dressing Directions

Whisk together the vinegar, pomegranate molasses, honey, mustard, 1/4 teaspoon salt and 1/4 teaspoon pepper in a small bowl until combined. Slowly whisk in the oil until emulsified. The dressing will keep in the refrigerator, tightly covered, for up to 2 days. Yield: 1/2 cup

Coming Soon: 5 tips to staying healthy

during the holidays

Best wishes for a safe and healthy holiday season…



Recipe of the month

Grilled Leeks with Tarragon Vinaigrette

• 2 tablespoons tarragon white wine vinegar
• 1 tablespoon Dijon mustard
• Kosher salt and freshly ground black pepper
• 4 tablespoons extra-virgin olive oil, plus for brushing
• 8 medium to small leeks, dark green parts removed

In a bowl or jar, combine the vinegar, mustard and some salt and pepper. Whisk to combine, and then slowly pour in the olive oil while whisking. Set aside.

Trim the roots off the leeks, leaving some of the root end intact so the leeks hold together. Cut the leeks in half lengthwise and rinse very well–they are usually pretty sandy and dirty.

Add about 1 inch of water to a large pot over medium-high heat. Insert a steamer basket and set the leeks into the steamer. Cover and cook until softened and tender when the white end is pierced with a paring knife, about 5 minutes. Remove the leeks from the steamer, pat dry and transfer to a shallow dish. Brush with olive oil and season generously with salt and pepper.

Heat a grill pan or grill to medium-high heat. Add the leeks, cut-side down, and cook until grill marks form, about 3 minutes. Flip and repeat. Remove to a serving platter, drizzle over some of the vinaigrette and sprinkle with the hazelnuts.

Here are some healthy brands I recommend—

With a special section on gluten free products

  • Applegate cold cuts- organic ham, turkey, cheese, chicken slices available in most deli sections of supermarkets! They have both “natural” and “organic”—buy the organic.*
  • Julian Bakery – buy their breads and grain-free paleo wraps online at
  • Stevita brand liquid stevia and stevita delight chocolate drink mix available online at
  • Blue Mountain Organics online for organic sprouted nuts and nut butters, gluten-free cereals, snacks and grain-free curry wraps.
  • Lundberg rice cakes
  • Peccorino Romano Sheep Cheese
  • Goat Cheese (any brand)
  • MaraNatha organic nut butters
  • Woodstock organic tahini
  • Amy’s Organic soups and frozen dinners
  • Arrowhead Mills
  • Redwood Hill Farm goat yogurt-available at Whole Foods
  • Old Chatham Sheep Yogurt
  • Once Again organic sunflower seed butter
  • Pacific organic almond milk
  • Pacific organic free range chicken broth and veggie broth—great for sautéing meats, poultry, fish
  • Bulletproof upgraded coffee
  • Coconut Secret raw coconut flour
  • Stoneyfield organic butter
  • Simply Organic spices
  • Tree of Life organic frozen berries
  • Lily’s stevia sweetened dark chocolate
  • Oak Knoll Dairy goat yogurt
  • Dream Protein powder (whey is from grass fed cows)
  • Eden gomazio (sesame seed and salt condiment)
  • So Delicious coconut and almond milk and yogurt (dairy free)
  • Arctic Zero Ice Cream (35 calories, 5 g sugar per serving)
  • Spectrum brand oils including organic virgin coconut oil
  • Traditional Medicinals teas for colds and flu, digestive ailments, calming tea, etc. most supermarkets/health food stores


Gluten Free Favorite Brands:

  • Lundberg rice chips –fiesta lime best flavor-has dairy
  • Glutino Flax Bread(frozen) (shop rite)—very good toasted and rosemary and olive oil crackers—very good!
  • Mary’s Gone gluten free crackers (shop rite)


  • French Meadow Bakery multigrain (frozen Health Shop)
  • La Tortilla Factory gluten free wraps (shop rite and Kings) they are near the deli section on a single stand.
  • Against the Grain Gourmet Pesto Pizza- available at Whole Foods — delicious pizza!
  • Ancient Harvest Quinoa Flakes instant hot cereal
  • Most tamari (soy sauce) is made with wheat so I recommend buying the wheat free:
  • San J organic wheat free Tamari crackers
  • San J Tamari brown rice sesame crackers
  • The Grainless Baker
  • Udi’s Gluten Free breads (frozen)
  • Lydia’s Organics
  • Ancient Harvest red quinoa
  • Bob’s Red Mill gluten free steel cut oats and golden flax seed meal*
  • Boomi Bar
  • 22 Days PROTEIN BAR – MADE WITH RAW AND ORGANIC SUPERFOODS – Always USDA Organic – Vegan – Non-GMO – Gluten-free – Dairy-free – Plant-based
  • slim bars

What’s safer and more effective than a flu shot this season?

Nutrametrix OPC-3 is an isotonic blend of 3 potent anti-oxidants1 that is effective in both preventing and ridding symptoms of the flu, the common cold, and seasonable allergies.2 Many people experience colds twice a year when the seasons shift from summer to fall and from winter to spring. Testimonials from people around the globe taking OPC-3 report a profound decrease in allergy symptoms along with the number of colds and the flu they get as the seasons change.
What do we know about influenza?

  •  Over 200 viruses cause both true influenza and influenza-like illness, producing the same symptoms (fever, headache, aches, pains, cough and runny noses). These may keep you in bed for a week or more.
  • At best, vaccines may only be effective against influenza A and B, which represent less than 10% of all circulating viruses.
  • Annually, the World Health Organization estimates which viral strains should be included in the next season’s vaccinations but again, this represents only a few out of more than 200 viruses.

    Nutrametrix formulated this product to out-perform all other OPCs on the market by making it isotonic—the same concentration as your body fluids– for faster absorption and bioavailability. Findings demonstrate that the flavonoid mixture provided in isotonic OPC-3 is significantly more bioavailable in humans, in terms of antioxidant activity than an equivalent mixture in tablet form. Furthermore, the isotonic OPC-3 formulation resulted in a stronger antioxidative effect than an equivalent mixture in tablet form.3

What’s more, OPC-3 is known for its ability to combat free radicals (toxins), provide relief from inflammation, stabilize and maintain healthy blood sugar and cholesterol levels as well as having heart-enhancing benefits. 4
So it makes sense to strengthen your immune system and your ability to resist viruses from inside out rather than depend on a flu vaccine which has very limited rather than broad effectiveness. Along with a diet of nutrient-dense, fresh, wholesome foods, OPC-3 can raise your resistance to the flu and give you the best chance of avoiding the dreaded flu this winter!

OPC-3 is available at our Nutrametrtix Store: If you need a registration number, please contact Dee, our office manager at 973-822-2529.

1. includes grape seed extract, red wine extract, pine bark extract or pycnogenol as well as citrus bioflavinoids and bilberry extract
2. “A large number of investigations have demonstrated a broad spectrum of pharmacological and therapeutic benefits of grape seed proanthocyanidins (GSP) {one of the 3 ingredients in OPC-3} against oxidative stress and degenerative diseases including cardiovascular dysfunctions, acute and chronic stress, gastrointestinal distress, neurological disorders, pancreatitis and various stages of cancer. Studies have shown this combination to be more effective than vitamin C and vitamin E”. Free radical scavenging, antioxidant and cancer chemoprevention by grape seed proanthocyanidin: an overview. Mutation Research 2014 Oct;768:69-73. doi: 10.1016/j.mrfmmm.2014.04.004. Epub 2014 Apr 19.
3. Accelerated antioxidant bioavailability of OPC-3 bioflavonoids administered as isotonic solution. Phytother Res. 2009 Jun;23(6):775-7. doi: 10.1002/ptr.2651.
4. Improvement in Circulation and in Cardiovascular Risk Factors With a Proprietary Isotonic Bioflavonoid Formula OPC-3® ANGIOLOGY August/September 2008 vol. 59 no. 4 408-414

The Role of Nutrition and Nutritional Supplements in the Treatment of Dyslipidemia – Mark Houston MD Clin Lipidology. 2014;9(3):333-354.

Patients often ask for alternative treatments to statin drug therapy to reduce the risk of cardiovascular disease and cardiovascular incidents such as stroke and heart attack.
This extensive review of the scientific literature by Dr. Mark Houston is offered to give you the most up-to-date information by a recognized expert in the field. He has treated thousands of patients successfully using these methods and explains why he routinely orders expanded lipid profiles on all his patients which we offer through Spectracell Labs and Singulex Labs at our clinic. Although lengthy and technical, I believe that most of this review is understandable and I am available to discuss it further and answer any questions you may have. I trust that you will feel empowered to learn more about your ability to maintain your good health and prevent disease and premature disability.

{References for this article are available upon request—14 pages}
Mark C. Houston, MD, MS, ABAAM, FACP, FAHA
Dr. Mark Houston is Associate Clinical Professor of Medicine at Vanderbilt University School of Medicine and Director of the Hypertension Institute at Saint Thomas Hospital in Nashville, TN.
Dr. Houston has presented over 10,000 lectures nationally and internationally and published over 200 articles and scientific abstracts in peer reviewed medical journals. Four best selling books that he has authored are the Handbook of Antihypertensive Therapy, Vascular Biology for the Clinician, What Your Doctor May Not Tell You About Hypertension and Hypertension Handbook for Students and Clinicians. He has also authored the new Hypertension Handbook by Wiley/Blackwell in Oxford, UK.
He is triple boarded certified by the American Board of Internal Medicine the American Society of Hypertension (ASH) and the American Board of Anti-Aging and Regenerative Medicine (ABAARM)). He has a Masters of Science degree in HUMAN NUTRITION.
Dr Houston was selected as one of the top Physicians in Hypertension in the US in 2008 by the Consumer Research Council, and by USA Today as one of the Most Influential Doctors in the US in both Hypertension and Hyperlipidemia twice in 2009.

The combination of a lipid-lowering diet and scientifically proven nutraceutical supplements have the ability to significantly reduce LDL cholesterol, decrease LDL particle number, increase LDL particle size, lower triglycerides and VLDL, increase total and type 2 b HDL and improve HDL functionality.
In several prospective clinical trials, coronary heart disease and cardiovascular disease have been reduced with optimal nutrition and/or administration of several nutraceutical supplements, including omega 3 fatty acids, red yeast rice, α-linolenic acid and niacin. A combined program of nutrition and nutraceutical supplements represents a scientifically valid alternative for patients who are statin intolerant, cannot take other drugs for the treatment of dyslipidemia or in those who prefer alternative therapies. This new approach to decrease dyslipidemic-induced vascular disease recognizes and treats the multiple steps that are involved in the development of atherosclerosis. The purpose of this review is to establish the scientific validity, efficacy and safety of combined nutrition and nutraceutical supplements for treating dyslipidemia without drugs for those patients intolerant of pharmacologic therapies or those who have preference for nondrug treatments.
This extensive review was done through analysis of all published articles in English on the topic of nutrition and nutraceutical supplements for the treatment of dyslipidemia that were available through the NIH and National Library of Congress publications (PubMed).
Genetics, epigenetics, chronic inflammatory micro- and macro-nutrient intake, obesity (visceral obesity), chronic infections, toxins and some specific pharmacological agents including some of the older β-blockers and the thiazide or thiazide-like diuretics, tobacco products, Diabetes Mellitus and lack of exercise contribute to dyslipidemia.[5,6]
Several genetic phenotypes, such as APOE, result in variable serum lipid responses to diet, as well as contributing to Coronary Heart Disease [CHD] and Myocardial Infarction [MI heart attack] risk.[7,8] In addition, HDL proteomics that affect PON-1 and SR–BI increase Cardiovascular Disease [CVD].[9] The sortilin I allele variants on chromosome 1p13 increase LDL and CHD risk by 29%.[10]
Recent studies suggest that increasing dietary cholesterol intake will NOT significantly alter serum total or LDL cholesterol levels or CHD risk. Some saturated fats, depending on their carbon chain length, may have minimal influences on serum lipids and CHD risk, whereas monounsaturated and polyunsaturated fats have a favorable influence on serum lipids and CHD risk. Increased refined carbohydrate intake may be more important in changing serum lipids and lipid subfractions than saturated fats and cholesterol. Refined carbohydrates have more adverse effects on insulin resistance, atherogenic LDL, small dense LDL, LDL particle number (LDL –Particles [LDL-P], VLDL, triglycerides, total HDL, HDL subfractions and HDL particle number, thus contributing to CHD risk more than saturated fats.[5,11–17]
The validity of the “Diet Heart Hypothesis” that implies that dietary saturated fats, dietary cholesterol and eggs increase the risk of CHD has been questioned.[12–14] Trans-fatty acids have definite adverse effects on serum lipids and increase CVD and CHD risk but omega 3 fatty acids and monounsaturated fats improve serum lipids and reduce CVD risk.[5,11–17]Trans-fats suppress TGF-β responsiveness, which increases the deposition of cholesterol into cellular plasma membranes in vascular tissue.[16]
Expanded lipid profiles that measure lipids, lipid subfractions, particle size and number, and Apo lipoprotein B and A are preferred to standard lipid profiles that measure only the total cholesterol, LDL, TG or HDL. These expanded lipid profiles such as the lipoprotein particles (SpectraCell Laboratories and Singulex, nuclear magnetic resonance (Liposcience), Berkley Heart Labs, Boston Heart Labs, Health Diagnostics Lab and vertical auto profile (Atherotec), improve serum lipid analysis and CHD risk profiling.[24,25] It is now proven that LDL-P is the primary lipid parameter that drives the risk for CHD and MI, as well as coronary artery calcification as measured by CT angiogram..[26,27] Dense LDL type B or LDL type 3 and type 4 have secondary roles in CHD only if the LDL-P is elevated.
Nutraceutical supplement management of dyslipidemia has been infrequently reviewed.[5–6,54] New important scientific information and clinical studies are required to understand the present role of these natural agents in the management of dyslipidemia.[5–6,54] Clinical trials show excellent reductions in serum lipids and CHD with niacin, omega 3 fatty acids, red yeast rice, fiber and alpha linolenic acid. Smaller studies show improvements in various biomarkers for CVD such as inflammation, oxidative stress, vascular immune function, plaque stability, progression and regression.[5,54–55] In addition studies have used surrogate vascular markers, show improvement in arterial stiffness and improved elasticity, reduction in pulse wave velocity and augmentation index, decreased carotid intimal medial thickness (CIMT) and obstruction, coronary artery plaque progression, coronary artery calcium score by electron beam tomography (EBT) and CT angiogram as well as decrease in generalized atherosclerosis and improvement in endothelial function.[5,54–56]
Red Yeast Rice
Red yeast rice (RYR; Monascus Purpureus) is a fermented product of rice that contains monocolins, which inhibit cholesterol synthesis via HMG CoA reductase and thus has ‘statin-like’ properties (13 natural statins).[5,54,74–96] RYR also contains ergosterol, amino acids, flavonoids, trace elements, alkaloids, sterols, isoflavones and monounsaturated fatty acids that improve the lipid profile. RYR administered orally to adults subjects with dyslipidemia at 2400 mg per day reduced LDL-C by 22% (p < 0.001), TG by 12% with little change in HDL.[5,54,74] RYR reduces the risk of abdominal aortic aneurysms by suppressing angiotensin II levels.[75] RYR also is effective in mouse models against obesity-related inflammation, insulin resistance and nonalcoholic fatty liver disease.[76] RYR in conjunction with berberine improves insulin resistance, glucose and lipids in subjects with or without metabolic syndrome.[86,89,95] RYR, policosanol and artichoke leaf extract decrease LDL-C significantly[77,84] as did RYR with plant stanols.[83] RYR with berberine, policosanol, astaxanthin, coenzyme Q10 and folic acid reduce LDL-C by 21.1% similar to pravastatin 10 mg per day with a 4.8% increase in HDL-C over 8 weeks.[92]
RYR inhibits TNF-α and MMP-2 and MMP-9 (metalloproteinases),[79] suppresses caveolin-1, increases eNOS (endothelial nitric oxide synthase) expression, improves abnormal hemorheology,[78] increases adiponectin,[85] improves the leptin-to-adiponectin ratio,[92] lowers HS CRP (high sensitivity CRP) and improves vascular remodeling parameters such as MMP-2 and MMP-9,[87] reduces expression of tissue factor, ox-LDL and reduces thrombosis in animal models by suppressing NADPH oxidase and extracellular signal-regulated kinases activation.[90] In a recent placebo-controlled Chinese study of 5000 subjects over 4.5 years, an extract of RYR reduced LDL 17.6% (p < 0.001) and increased HDL 4.2% (p < 0.001).[96] CV mortality fell 30% (p < 0.005) and total mortality fell 33% (p < 0.0003) in the treated subjects. The overall primary end point for MI and death was reduced by 45% (p < 0.001). Recent meta-analysis and clinical trials of RYR for dyslipidemia and CVD end points confirmed these positive findings.[81,82,93–94] A highly purified and certified RYR must be used to avoid potential renal damage induced by a mycotoxin, citrinin.[5,54,74] The recommended dose is 2400–4800 mg/day of a standardized RYR. No adverse effects have been reported such as myalgias or liver dysfunction with long term use nor is there any interference with the CYP450 enzymes.[90] Although reductions in coenzyme Q 10 may occur in predisposed patients and those on prolonged high dose RYR, due to its weaker ‘statin-like’ effect this is not as likely as with statins. RYR is an excellent alternative to patients with statin-induced myopathy[5,54,74,88,96] and in statin-intolerant patients with or without Type 2 DM in conjunction with the Mediterranean diet to effectively manage their dyslipidemia.[91]
Green Tea Extract & Green Tea (EGCG)
Catechins, especially EGCG, may improve the lipid profile by interfering with micellar solubilization of cholesterol in the GI tract and reduce absorption.[5] In addition, EGCG reduces the fatty acid gene expression, inhibits HMG CoA reductase, increases mitochondrial energy expenditure, reduces ox-LDL, increases PON-1, upregulates the LDL receptor, decreases APO-B lipoprotein secretion from cells, mimics the action of insulin, improves endothelial dysfunction, activates Nrf2, increases HO-1 expression, decreases inflammation, displaces caveolin-1 from cell membranes, increases nitric oxide, reduces endothelial inflammation and decreases body fat.[5,106–109]
A meta-analysis of human studies of 14 trials show that EGCG at 224–674 mg per day or 60 oz of green tea per day reduced TC 7.2 mg/dl and LDL 2.19 mg/dl (p < 0.001 for both). There was no significant change in HDL or TG levels.[110] The recommended dose is a standardized EGCG extract at 500–1000 mg per day.
Omega 3 Fatty Acids
Observational, epidemiologic and controlled clinical trials have shown significant reductions in serum TG, VLDL, decreased LDL particle number and increased LDL and HDL particle size as well as major reductions in all CVD events.[5,111–118] The DART trial demonstrated a decrease in mortality of 29% in men post MI and the GISSI prevention trial found a decrease in total mortality of 20%, CV deaths of 30% and sudden death of 45%. The Kuppio Heart Study demonstrated a 44% reduction in fatal and nonfatal CHD in subjects in the highest quintile of omega 3 intake compared with the lowest quintile.[5,111–112] Omega 3 FA reduce CHD progression, stabilize plaque, reduce coronary artery stent restenosis and CABG occlusion.[5,113] In the JELIS study, the addition of 1.8 g of omega EPA to a statin resulted in an additional 19% RRR in major coronary events and nonfatal MI and a 20% decrease in CVA.[5,114]
There is a dose-related reduction in VLDL of up to 50%, TG of up to 50%, with little to no change or decrease in total TC, LDL, APO B and no change to slight increase in HDL.[5,115–118] However, the number of LDL particles decreases and LDL particle size increases from small type B to large type A (increase of 0.25 nm). The antiatherogenic HDL 2b is also increased by up to 29%. The rate of entry of VLDL particles into the circulation is decreased and APOCIII is reduced, which allows lipoprotein lipase to be more active.[27] There is a decrease in remnant chylomicrons and remnant lipoproteins.[5,116] Patients with LDL over 100 mg/dl have reductions in total LDL and those that are below 80 mg/dl have mild increases.[117] However, in both cases the LDL particle number decreases, the dense LDL B increases in size to the less atherogenic LDL A particle and APO B levels decrease. There is a net decrease in the concentration of cholesterol carried by all atherogenic particles and decreases in non-HDL cholesterol. Omega 3 FA are anti-inflammatory, antithrombotic, lower BP and heart rate, improve heart rate variability,[5,111] decrease fatty acid synthesis, increase in fatty acid oxidation and reduce body fat and weight.[5] Omega 3 fatty acids are one of the only substances that lower Lp-LPA2.[27] Insulin resistance is improved and there are no significant changes in fasting glucose or hemoglobin A1C with long-term treatment.[119] Doses of 3 g per day of combined EPA and DHA at a 3:2 ratio with GLA at 50% of the total EPA and DHA content and 700 mg of γ/δ tocopherol at 80 and 20% α-tocopherol per 3 g of DHA and EPA are recommended.[5] DHA and EPA may have variable but favorable effects on the various lipid levels.[5,115–116,119] EPA does not usually increase LDL, is less effective in lowering TG than DHA and does not alter the LDL and HDL particle size. Although DHA may increase total LDL, it increases LDL and HDL size and lowers TG more.[118] The combination of plant sterols and omega 3 fatty acids is synergistic in improving lipids and inflammation.[70] New free fatty acid forms of omega 3 fatty acids have a fourfold greater area under the plasma n-3 PUFA curve than prescription Lovaza and thus a more potent reduction in TG levels.[119] The data of krill oil on dyslipidemia is limited to only two studies in humans.[120,121] The first study[120] showed a dose-related response of LDL-C reduction up to 39%, TG reduction of 27% and HDL elevation of 60%.[120] Another study[121] showed minimal reductions in TG of 10%, but the decrease was not sustained during long-term treatment. These findings with krill oil are very disparate and the studies are not confirmatory. Krill oil is not recommended at this time for the treatment of dyslipidemia.
Flax seeds and flax lignan complex with secoisolariciresinol diglucoside and increased intake of ALA from other sources such as walnuts have been shown in several meta-analyses to reduce TC and LDL by 5–15%, Lp(a) by 14%, TG by up to 36% with either no change or a slight reduction in HDL.[5,122–124] These properties do not apply to flax seed oil. In the Seven Countries study CHD was reduced with increased consumption of ALA. In the Lyon diet trial at the end of 4 years, intake of flax reduced CHD and total deaths by 50–70%.[5] Flax seeds contain fiber, lignins and phytoestrogens and decrease the levels of 7-α-hydroylase and acyl CoA cholesterol transferase.[5,122–124] Flax seeds and ALA are anti-inflammatory, reduce HS-CRP, decrease TG, increase HDL, decrease insulin resistance and risk of Type 2 DM, reduce visceral obesity and systolic BP, increase eNOS and improve endothelial dysfunction. Flax decreases vascular smooth muscle hypertrophy, reduces oxidative stress, increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase-1 expressions and farnesoid X receptor’s mechanisms of action which, retard the development of atherosclerosis..[5,122–126] The dose required for these effects is between 14 to 40 grams of flax seed per day.[5,122–126] Chia seeds (Salvia hispanica) are the richest botanical source of ALA at 60% weight/volume.[125] The dose of Chia seeds is 25 g per day.
Tocotrienols- form of Vitamin E
Tocotrienols are a family of unsaturated forms of vitamin E termed α, β, γ and δ.[5] The γ- and δ-tocotrienols lower TC up to 17%, LDL 24%, APO B 15%, and Lp(a) 17% with minimal changes in HDL or APO-A1 in 50% of subjects at doses of 200 mg per day given at night with food.[5,135–137] The γ/δ form of tocotrienols inhibits cholesterol synthesis by suppression of HMG-CoA reductase activity by two post-transcriptional actions.[5,135–137] These include increased controlled degradation of the reductase protein and decreased efficiency of translation of HMG CoA reductase mRNA. These effects are mediated by sterol binding of the reductase enzyme to the endoplasmic reticulum membrane proteins called INSIGS.[136] The tocotrienols have natural farnesylated analogs of tocopherols that give them their effects on HMG CoA reductase.[136] In addition, the LDL receptor is augmented and they exhibit antioxidant activity.
The tocotrienol dose is very important, as increased dosing will induce its own metabolism and reduce effectiveness, whereas lower doses are not as effective.[5] Also concomitant intake (less than 12 h) of α-tocopherol reduces tocotrienol absorption. Increased intake of alpha tocopherol over 20% of total tocopherols may interfere with the lipid-lowering effect.[5,135]
Tocotrienols are metabolized by successive β-oxidation then catalyzed by the CYP450 enzymes 3A4 and CYP4F2.[5] The combination of a statin with γ/δ tocotrienols further reduces LDL cholesterol by 10%.[135] The tocotrienols block the adaptive response of upregulation of HMG-CoA reductase secondary to competitive inhibition by the statins.[5,135] Carotid artery stenosis regression has been reported in approximately 30% of subjects given tocotrienols over 18 months. They also slow progression of generalized atherosclerosis.[5,137] The recommended dose is 200 mg of γδ tocotrienol at night with food.
Pantethine – form of Vitamin B5
Pantethine is the disulfide derivative of pantothenic acid and is metabolized to cystamine-SH which is the active form in treating dyslipidemia.[5,138–142] Over 28 clinical trials have shown consistent and significant improvement in serum lipids. TC is decreased 15%, LDL by 20%, APO B by 27.6%, and TG by 36.5% over 4–9 months. HDL and APO A1 are increased 8%.[5,138–143] The effects on lipids are slow with peak effects at 4 months but may take up to 6- 9 months.[5,138–143] In addition, pantethine reduces lipid peroxidation of LDL, decreases lipid deposition, intimal thickening and fatty streak formation in the aorta and coronary arteries.[5,138–143] Pantethine inhibits cholesterol synthesis and accelerates fatty acid metabolism in the mitochondria by inhibiting hepatic acetyl-CoA carboxylase, increases CoA in the cytoplasm which stimulates the oxidation of acetate at the expense of fatty acid and cholesterol synthesis, and increases the Krebs cycle activity.[5,138–143] In addition, cholesterol esterase activity increases and HMG-CoA reductase activity decreases.[5,138–143] There is 50% inhibition of FA synthesis and 80% inhibition of cholesterol synthesis.[5] Its lipid effects are additive to statins, niacin and fibrates. The recommended effective dose is 300 mg three-times per day or 450 mg twice per day with or without food.[5,138–143]
Resveratrol reduces ox-LDL, inhibits ACAT activity and cholesterol ester formation, increases bile acid excretion, reduces TC, TG and LDL, increases PON-1 activity and HDL, inhibits NADPH oxidase in macrophages and blocks the uptake of modified LDL by CD36 SR (scavenger receptors).[155,156] N Acetyl Cysteine (NAC) has this same effect on CD 36 DR and should be used in conjunction with resveratrol.[155] The dose of trans-resveratrol is 250 mg per day and NAC is 1000 mg twice per day.
Curcumin, phenolic compound in tumeric and curry,[5,157] induces changes in the expression of genes involved in cholesterol synthesis such as the LDL receptor mRNA, HMG CoA reductase, SREBP, cholesterol 7-α-hydrolyze, PPAR, LXR, affects the expression of genes involved in leukocyte adhesion and transdendothelial migration to inhibit atherosclerosis.[5,157–160] In one human study of ten patients consuming 500 mg per day of curcumin, the HDL increased 29% and total cholesterol fell 12%.[5,157] A recent meta-analysis of five studies of 133 subjects did not indicate a significant effect of curcumin on any of the lipid parameters.[160] Larger randomized clinical trials are needed to determine the lipid-lowering effects and potential reduction in CV effects with curcumin.
Pomegranate increases PON-1 binding to HDL and levels of PON-2 in macrophages. It is a potent antioxidant that increases total antioxidant status, lowers ox-LDL, decreases antibodies to ox-LDL, inhibits platelet function, reduces glycosylated LDL, decreases macrophage LDL uptake and reduces lipid deposition in the arterial wall.[161–166] These changes impede the progression of carotid artery IMT and lower blood pressure especially in subjects with the highest oxidative stress, known carotid artery plaque and the greatest abnormalities in TG and HDL levels.[161–166] Consuming about 8 oz of pomegranate juice per day or one to two cups of pomegranate seeds is recommended.
The full article lists additional nutraceuticals not covered here.

How to keep your gut microbiota happy—and yourself healthy:


• Avoid any food that irritates your gut or causes GI symptoms such as gas, bloating and diarrhea
• Eat slowly, chew each bite 30 times
• Choose real, whole unadulterated foods as your primary source of nutrition
• Eat plenty of fermentable fibers (starches like sweet potato, yam, yucca)
• Eat soluble fibers such as flax seed, brussel sprouts and black beans daily
• Eat fermented foods like kefir, yogurt, sauerkraut, kim chi
• Treat any intestinal pathogens (such as parasites) that may be present
• Manage your stress
• Get plenty of sleep
Which Probiotic is Best?
I recommend alternating between two or three products to obtain the largest diversity of species with a high count. These three are highly recommended and all are available at our doctor supplement store:
Our registration code is CO520. The general dose is one per day.
1. Klaire Ther-biotic Complete caps or powder
2. Researched Nutritionals Prescript-Assist caps (requires no refrigeration)
3. Innate Response Formulas Flora 20-14 Ultra Strength caps

The key to your health starts in your gut: 100 trillion reasons why


Patients often ask me to recommend the four or five most important nutrients that everyone should take. The first one that comes to mind is probiotics. Our gut microbiota provide protection from infection, regulate metabolism, help irritable bowel, constipation, and diarrhea, and break down and rebuild hormones to name just a few. We can’t live without them! Antibiotics destroy them. Antibiotic wipes, soaps, toothpastes and other antimicrobial compounds, particularly those with Triclosan, make you more likely to get sick rather than to get healthy.

2,500 years ago Hippocrates said, “All disease begins in the gut.” Today, modern science is proving him right.
Many diseases result from having a low diversity of good bacteria on your skin, in your nose or in your gut. The benefits of having a high diversity of good bacteria are multiple as outlined above. A healthy person should have about 4 pounds of favorable bacteria in his or her large intestine!
In addition, absorption of vital nutrients from foods and supplements such as vitamin D is dependent on the health of the gastrointestinal tract. So if the tract is inflamed, if it propels the food bolus too quickly or slowly (known as transit time), or if the junctions between cells are too “loose” (known as “leaky gut” or increased permeability), these will contribute to impaired absorption.
Recent studies suggest that approximately 70 to 80 percent of the body’s immune cells are in the gut. And the gut has even been called a second brain because it secretes more brain chemicals like serotonin and dopamine than the brain itself. A curious finding from studies of children with autism spectrum disorders shows that they are more likely to suffer from genetically linked gastrointestinal disorders such as celiac disease. And when they alter their diets, some improve dramatically.
In 2008 the National Institutes of Health launched The Human MicroBiome Project in which investigators have been following 242 healthy people, periodically sampling bacteria from their gut and other locations in the body. Five years into the research, findings gathered by teams have discovered something perhaps more mind boggling than any discovery in medical history—the gut microbiome (consisting of all the microbes in each person) contains 100 trillion microorganisms from a thousand different species. Also, the microbiota in each of us has more than 100 times as many genes as our own set of genes.
So it’s not incorrect to say that we’re more microbe than human because over 90% of the genetic diversity in our bodies is due to microbes.1 A recent study even suggests that altering gut bacteria may help put lupus into remission. 2  Researchers on another project also noted that changes in intestinal barrier function (leaky gut) are present in multiple sclerosis and suggested that future treatments for MS should not only focus on the central nervous system, but also on the intestines by repairing and restoring the intestinal barrier.3

How have our guts gotten so out of whack? Poor diet, overuse of antibiotics, artificial sweeteners, high alcohol intake, cesarean births, a decline in breastfeeding, environmental toxins, chronic stress, and sleep deprivation all have a negative effect on the gut bacteria and the gut lining that we need for healthy digestion—and by extension, our health and longevity.

1.The Impact of Diet and Lifestyle on Gut Microbiota and Human Health  Michael A. Conlon, Anthony R. Bird Nutrients. 2015 January; 7(1): 17–44. Published online 2014 December 24. doi: 10.3390/nu701001  PMCID:  PMC4303825

2. Intestinal barrier damage in multiple sclerosis
Date: September 4, 2014  Source: Lund University
3. Intestinal Barrier Dysfunction Develops at the Onset of Experimental Autoimmune Encephalomyelitis, and Can Be Induced by Adoptive Transfer of Auto-Reactive T Cells
Published online 2014 Sep 3. doi:  10.1371/journal.pone.0106335  PMCID: PMC4153638